The standard delineation of Evidence-Based Practice (EBP) originates from Dr. David Sackett, which refers to a problem-solving, explicit, and conscientious approach useful in clinical practice. The plan integrates individual clinical know-how with the best existing clinical evidence within a considered systematic research. Therefore, EBP not only applies the best research evidence based on decisions but also use the training, skills, and experience as a health professional and considering conditions of patients and values such as financial position and social support (Crabtree et al., 2016). The process of healthcare’s integrating its entire information is referred to as clinical reasoning. The ultimate goal of the EBP adoption is to enhance quality in healthcare, reduce costs, increase patient outcomes, and strengthen clinicians, commonly referred to as quadruple healthcare aims.  Healthcare systems and hospitals, mainly in the United States, continually strive to realize the quadruple healthcare aims and enhance the safety of patients care. The United States healthcare system and hospitals articulate well-designed EBP vision integrated with well-designed infrastructure that has developed a supportive organizational culture for evidence-based improved care (Sikka, Morath & Leape, 2015). However, challenges with quality, for instance, inevitable medical flaws reveal as the third prominent cause of death mainly in the U.S with scarce clinicians. EBP publishes as the best strategy to achieve the quadruple objective as it is not the classic of care in numerous healthcare systems since practices steeped in organizations and tradition that promotes a culture that endures succeeding using EBP approach in such circumstances.  In recent times, there has been an outburst of scientific evidence existing to direct health experts. However, the American Association of Colleges of Nursing (AACN) initiated a significant curriculum investment development, with the introduction of the new program that focuses on health care systems on the application of evidence mainly for clinical decision making (Boller, 2017). Besides, the body develops safety and quality education in the field of nursing using the EBP approach to enhance the quality of care. The organization through the use of EBP realized tremendous benefits in reduced costs, patient-centered with a better understanding of the varied aspect of the evidence-based practice such as knowledge transformation and utilization processes in healthcare (Crabtree et al., 2016). To this extent, the application of EBP is evident and irrefutable.   References Boller, J. (2017). Nurse educators: Leading health care to the quadruple aim sweet spot. Journal of Nursing Education, 56(12), 707-708. doi:10.3928/01484834-20171120-01 Crabtree, E., Brennan, E., Davis, A., & Coyle, A. (2016). Improving patient care through nursing engagement in evidence-based practice. Worldviews on Evidence-Based Nursing, 13(2), 172–175. doi:10.1111/wvn.12126 Sikka, R., Morath, J. M., & Leape, L. (2015). The Quadruple Aim: Care, health, cost, and meaning in work. BMJ Quality & Safety, 24, 608–610. doi:10.1136/bmjqs-2015-004160